We develop a Boolean model to explore the dynamical behaviour of budding yeast in response to osmotic and pheromone stress. Our model predicts that osmotic stress halts the cell cycle progression in either of four possible arrest points. The state of the cell at the onset of the stress dictates which arrest point is finally reached. According to our study and consistent with biological data, these cells can return to the cell cycle after removal of the stress. Moreover, the Boolean model illustrates how osmotic stress alters the state transitions of the cell. Furthermore, we investigate the influence of a particular pheromone based method for the synchronisation of the cell cycles in a population of cells. We show this technique is not a suitable method to study one of the arrest points under osmotic stress. Finally, we discuss how an osmotic stress can cause some of the so called frozen cells to divide. In this case the stress can move these cells to the cell cycle trajectory, such that they will replicate again.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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