Reference: de Graaf CA and van Steensel B (2013) Chromatin organization: form to function. Curr Opin Genet Dev 23(2):185-90

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Abstract


Recent developments in technology have made it possible to create high resolution genome-wide maps of histone marks, DNA binding proteins and physical interactions along genomic regions. Chromatin features are found together in different combinations, dividing the genome up into domains with distinct functional properties. Microscopy and chromatin conformation capture techniques have shown that the 3D structure of chromosomes is constrained by nuclear features and functional links between different parts of chromatin. These results provide insights about the 3D and domain organization of the genome and their connection to gene regulation and other nuclear functions.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't | Review
Authors
de Graaf CA, van Steensel B
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Gene Species Gene ID Strain background Direction Details Source Reference