Polyadenylation in eukaryotes has traditionally been viewed as a means of stabilizing mRNAs and enhancing their translation. It is now appreciated, however, that there are multiple pathways to polyadenylation that can have opposing consequences for RNA stability and gene expression. The focus of this article will be on nuclear polyadenylation, highlighting the recent advances in our understanding of noncanonical polyadenylation events and how their outcomes contrast with those of normal mRNA polyadenylation. Much insight into these pathways derives from studies in yeast, although data from metazoans are now emerging which implicate widespread use of polyadenylation as a means of genetic regulation. We show herein that short upstream mRNA polyadenylation events occur in cells undergoing enhanced herpesvirus-mediated mRNA turnover, thereby extending the evidence for poly(A)-stimulated RNA decay in mammals.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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