Reference: Warit S, et al. (2008) Cloning and heterologous expression of Cryptococcus neoformans CnSRB1 cDNA in Saccharomyces cerevisiae. Southeast Asian J Trop Med Public Health 39(3):484-91

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Abstract


In this study, we report the results of cloning, sequencing and functional analysis by complementation test of the putative Cryptococcus neoformans homolog CnSRB1. The nucleotide sequence revealed 63% identity, and the deduced amino acid sequence showed 66 and 64% identity to its respective homolog of Saccharomyces cerevisiae and Candida albicans, respectively. Functional complementation test indicated that the putative CnSRB1 gene could compensate the defect caused by a mutation in ScSRB1 in the S. cerevisiae srb1 mutant. Taken together, these results suggest that the putative CnSrblp is a functional homolog of ScSrb1p.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Warit S, Stateva LI, Palittapongarnpim P
Primary Lit For
PSA1