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Reference: Lee HG, et al. (2008) High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae. Genome Biol 9(1):R2

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Abstract

We present an approach for identifying condition-specific regulatory modules by using separate units of gene expression profiles along with ChIP-chip and motif data from Saccharomyces cerevisiae. By investigating the unique and common features of the obtained condition-specific modules, we detected several important properties of transcriptional network reorganization. Our approach reveals the functionally distinct coregulated submodules embedded in a coexpressed gene module and provides an effective method for identifying various condition-specific regulatory events at high resolution.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Lee HG, Lee HS, Jeon SH, Chung TH, Lim YS, Huh WK
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