Reference: Abrat OB, et al. (2007) [Acid stress increases the activity of superoxide dismutase and catalase in the yeast Saccharomyces cerevisiae]. Ukr Biokhim Zh (1999) 79(2):17-23

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Abstract


The effect of acetic acid on survival and activity of superoxide dismutase and catalase in different Saccharomyces cerevisiae strains has been studied. The cell survival decreases with an increase of acetic acid concentration in all strains studied. YBB14 (deltapdr12) and YAK120 (deltawar1) strains are more sensitive to acetate than their parental strain W303-1A. It can be assumed that ABC-transporter Pdr12p and its transcriptional regulator War1p play an important role in the transportation of acetic acid from the cell. Incubation of the yeast with 150-200 mM CH3COOH causes the increase of superoxide dismutase and catalase activities in the wild strain. At the same time, the enzyme activities rise with the increase of time exposure. However, superoxide dismutase and catalase deficit does not decrease yeast survival under conditions used in this study.

Reference Type
Journal Article
Authors
Abrat OB, Semchyshyn HM, Lushchak VI
Primary Lit For
WAR1 | PDR12

Phenotype Annotations 2 entries for 2 genes


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GenePhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetails
PDR12resistance to chemicals: decreased
classical geneticsnull
Allele: pdr12-Δ
W303 acetate
WAR1resistance to chemicals: decreased
classical geneticsnull
Allele: war1-Δ
W303 acetate
Showing 1 to 2 of 2 entries