Reference: Voronov AS, et al. (2006) [Evolutionary divergence of the ribosomal internal transcribed spacer 2 (ITS2) in lizards]. Mol Biol (Mosk) 40(1):45-51

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Abstract


During the pre-rRNA cleavage pathway, the excision of ITS2, a eukaryotic specific insertion, remains the most elusive processing step, even in yeast. Comparison of the ITS2 sequences in different organisms permits to reveal conservative, presumably functionally important elements as well as obtain new information about ITS2 divergence in evolution. We have cloned and sequenced the ITS2 of three lizard species, Agama caucasia (Agamidae), Darevskia armeniaca and Lacerta strigata (Lacertidae) and detected in them a set of specific and conservative structural elements employing secondary structure consensus for vertebrate ITS2. Furthermore, we have performed an alignment and comparative analysis of the ITS2 sequences for the two lizards families. It enables us to propose that modern lizard species formation in evolution was accompanied by ITS2 duplication in the rDNA of their common progenitors.

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English Abstract | Journal Article
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Voronov AS, Shibalev DV, Ryskov AP, Kupriianova NS
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