Autophagy, Cvt pathway and pexophagy belong to membrane transport routes, which are able to enwrap into double-membrane vesicles and deliver to the vacuole various cytosolic material, including organelles. Pexophagy is a selective pathway of vacuolar degradation of redundant peroxisomes and can be induced by certain changes of carbon sources in yeasts. Here we review the most general molecular mechanisms of autophagic transport routes with a special emphasis on their features and functions in the yeast peroxisome degradation. Special attention has been also paid to differences in functioning of the basic autophagic machinery during micro- and macroautophagic peroxisome degradation in methylotrophic yeasts. The requirements of autophagic pathways for the sources of membrane for transport vesicle formation are also analyzed. Finally, we point to the gaps in our understanding of peroxisome degradation, which should be filled for complete integration of pexophagy into the network of autophagic transport routes to the vacuole in yeast.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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