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Reference: Chen CZ and Collins RN (2005) Insights into biological functions across species: examining the role of Rab proteins in YIP1 family function. Biochem Soc Trans 33(Pt 4):614-8

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Abstract

The YIP1 family comprises an evolutionarily conserved group of membrane proteins, which share the ability to bind di-prenylated Rab proteins. The biochemical capability of YIP1 family proteins suggests a possible role in the cycle of physical localization of Rab proteins between their cognate membranes and the cytosol. YIP1 is essential for viability in yeast and a deletion of YIP1 can be rescued with the human homologue YIP1A. We have made use of this evolutionary conservation of function to generate a series of mutant alleles of YIP1 to investigate the biological role of Yip1p. Our findings indicate evidence for the participation of Yip1p in both Rab and COPII protein function; at present, we are not able to distinguish between the models that these roles represent, i.e. independent or dependent activities of Yip1p.

Reference Type
Journal Article | Review
Authors
Chen CZ, Collins RN
Primary Lit For
YIP1
Additional Lit For
YPT1 | YPT31 | YIP4 | YPT52 | YPT32 | YPT6 | GDI1 | YIP5 | VPS21

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Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details about experiment type and any other genes involved in the interaction.

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