Reference: Navarro RE and Blackwell TK (2005) Requirement for P granules and meiosis for accumulation of the germline RNA helicase CGH-1. Genesis 42(3):172-80

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Abstract


In Caenorhabditis elegans, lack of the conserved germline RNA helicase CGH-1 causes infertility and excessive levels of physiological germline apoptosis, a process that normally claims about half of all developing oocytes. In yeast the CGH-1 ortholog is a key component of degradative "processing (P) bodies," which may share some properties with germline protein-RNA complexes such as P granules. During oogenesis CGH-1 associates with P granules, but also accumulates to high levels in additional cytoplasmic particles. Here we show that appropriate levels and localization of CGH-1 depends on some P granule components and on mechanisms that establish meiotic development. At the same time, germ cell death is not increased by various abnormalities in P granules or meiosis. We conclude that in developing oocytes CGH-1 particles accumulate specifically in response to meiotic development and have distinct functions from P granules, and may be dynamic protein-mRNA structures.

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Journal Article | Research Support, N.I.H., Extramural | Research Support, U.S. Gov't, P.H.S.
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Navarro RE, Blackwell TK
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