Reference: Stern BM (2002) Mitosis: aurora gives chromosomes a healthy stretch. Curr Biol 12(9):R316-8

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Abstract


Attachment of sister chromatids to microtubules from opposite spindle poles--bi-orientation--generates tension at the kinetochores. The Ipl1/Aurora B kinase responds to the absence of tension at mono-oriented chromosomes and promotes microtubule turnover and spindle checkpoint activation until a stable bi-oriented attachment is achieved.

Reference Type
Journal Article
Authors
Stern BM
Review For
SLI15 | IPL1