Reference: Melo J and Toczyski D (2002) A unified view of the DNA-damage checkpoint. Curr Opin Cell Biol 14(2):237-45

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Abstract


Recent investigation of the DNA-damage checkpoint in several organisms has highlighted the conservation of this pathway. The checkpoint's signal transduction pathway consists of four conserved classes of molecules: two large protein kinases having homology to phosphatidylinositol 3-kinases, three "sensor" proteins with homology to proliferating cell nuclear antigen, two serine/threonine (S/T) kinases, and two adaptors for the S/T kinases. This review compares the role of these four classes of checkpoint proteins in humans and model organisms.

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Journal Article | Review
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Melo J, Toczyski D
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