In response to genotoxic agents and cell cycle blocks all eukaryotic cells activate a set of surveillance mechanims called checkpoints. A subset of these mechanisms is represented by the DNA damage checkpoint, which is triggered by DNA lesions. The activation of this signal transduction pathway leads to a delay of cell cycle progression to prevent replication and segregation of damaged DNA molecules, and to induce transcription of several DNA repair genes. The yeast Saccharomyces cerevisiae has been invaluable in genetically dissecting the DNA damage checkpoint pathway and recent findings have provided new insights into the architecture of checkpoint protein complexes, in their order of function and in the mechanisms controlling DNA replication in response to DNA damage.

• PMID: 10915872
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Reference Type

Journal Article | Research Support, Non-U.S. Gov't | Review

Authors

Foiani M, Pellicioli A, Lopes M, Lucca C, Ferrari M, Liberi G, Muzi Falconi M, Plevani1 P

Primary Lit For

MEC3

Additional Lit For

Review For