Reference: Cheung WL, et al. (2000) Acetylation and chromosomal functions. Curr Opin Cell Biol 12(3):326-33

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Abstract


Since the initial discovery of histone acetyltransferases, numerous reports have established that histone acetyltransferases and histone deacetylases regulate transcription by acetylating and deacetylating histones, respectively. Recent studies have focused on the effects of histone acetylation on gene expression regulation during development and the roles of histone hypoacetylation in the maintenance of centromeric structure, X-inactivation and genomic imprinting. Recent findings have also shown that the functions of non-histone proteins can also be regulated by acetylation. Together, these data highlight the importance of acetylation of histones and non-histone proteins in a variety of chromosomal functions.

Reference Type
Journal Article | Research Support, U.S. Gov't, P.H.S. | Review
Authors
Cheung WL, Briggs SD, Allis CD
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