Reference: Czaplinski K, et al. (1999) Should we kill the messenger? The role of the surveillance complex in translation termination and mRNA turnover. Bioessays 21(8):685-96

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Abstract


Eukaryotes have evolved conserved mechanisms to rid cells of faulty gene products that can interfere with cell function. mRNA surveillance is an example of a pathway that monitors the translation termination process and promotes degradation of transcripts harboring premature translation termination codons. Studies on the mechanism of mRNA surveillance in yeast and humans suggest a common mechanism where a "surveillance complex" monitors the translation process and determines whether translation termination has occurred at the correct position within the mRNA. A model will be presented that suggests that the surveillance complex assesses translation termination by monitoring the transition of an RNP as it is converted from a nuclear to a cytoplasmic form during the initial rounds of translation.

Reference Type
Journal Article | Review
Authors
Czaplinski K, Ruiz-Echevarria MJ, González CI, Peltz SW
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