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| Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|---|
| CAT5 | mitochondrial genome maintenance: increased | classical genetics | gain of function Allele: CAT5-91M allele is derived from strain RM11-1a and has a methionine rather than isoleucine codon at position 91 | S288C | Details: strain background is isogenic to S288C except that it carries the mkt1-D30G allele which is derived from the RM11-1a strain background; decreased frequency of small, nonrespiring (petite) colonies on glucose-containing medium, which arise from mutation or loss of the mitochondrial genome | Dimitrov LN, et al. (2009) PMID:19581448 | |
| ECM22 | mitochondrial genome maintenance: increased | classical genetics | null Allele: ecm22-Δ | S288C | Details: significant suppression of mtDNA loss during mitochondrial unfolded protein stress induced by mitoFluc, a fusion of an N-terminal mitochondrial targeting sequence with a misfolding-prone firefly luciferase variant | McNamara JT, et al. (2024) PMID:38126114 | |
| MIA40 | mitochondrial genome maintenance: increased | classical genetics | null Allele: mia40-Δ | S288C | Details: significant suppression of mtDNA loss during mitochondrial unfolded protein stress induced by mitoFluc, a fusion of an N-terminal mitochondrial targeting sequence with a misfolding-prone firefly luciferase variant | McNamara JT, et al. (2024) PMID:38126114 | |
| MIP1 | mitochondrial genome maintenance: increased | classical genetics | gain of function Allele: MIP1-661T allele based on a polymorphism derived from strain RM11-1a where the 661st amino acid is threonine in contrast to S288C derived strains where it is an alanine | S288C | Details: strain background is isogenic to S288C except that it carries the mkt1-D30G allele which is derived from the RM11-1a strain background; decreased frequency of small, nonrespiring (petite) colonies on glucose-containing medium, which arise from mutation or loss of the mitochondrial genome | Dimitrov LN, et al. (2009) PMID:19581448 | |
| OSH3 | mitochondrial genome maintenance: increased | classical genetics | null Allele: osh3-Δ | S288C | Details: significant suppression of mtDNA loss during mitochondrial unfolded protein stress induced by mitoFluc, a fusion of an N-terminal mitochondrial targeting sequence with a misfolding-prone firefly luciferase variant | McNamara JT, et al. (2024) PMID:38126114 | |
| PBP1 | mitochondrial genome maintenance: increased | classical genetics | null Allele: pbp1-Δ | S288C | Details: significant suppression of mtDNA loss during mitochondrial unfolded protein stress induced by mitoFluc, a fusion of an N-terminal mitochondrial targeting sequence with a misfolding-prone firefly luciferase variant | McNamara JT, et al. (2024) PMID:38126114 | |
| SAL1 | mitochondrial genome maintenance: increased | classical genetics | gain of function Allele: SAL1 wild-type allele from the RM11-1a strain background replacing the sal1-1 allele from S288C | S288C | Details: decreased frequency of small, nonrespiring (petite) colonies on glucose-containing medium, which arise from mutation or loss of the mitochondrial genome; strain background is isogenic to S288C except that it carries the mkt1-D30G allele which is derived from the RM11-1a strain background | Dimitrov LN, et al. (2009) PMID:19581448 | |
| SCY1 | mitochondrial genome maintenance: increased | classical genetics | null Allele: scy1-Δ | S288C | Details: significant suppression of mtDNA loss during mitochondrial unfolded protein stress induced by mitoFluc, a fusion of an N-terminal mitochondrial targeting sequence with a misfolding-prone firefly luciferase variant | McNamara JT, et al. (2024) PMID:38126114 | |
| SCY1 | mitochondrial genome maintenance: increased | classical genetics | overexpression | S288C | Details: significant suppression of mtDNA loss during mitochondrial unfolded protein stress induced by mitoFluc, a fusion of an N-terminal mitochondrial targeting sequence with a misfolding-prone firefly luciferase variant | McNamara JT, et al. (2024) PMID:38126114 |