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| Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|---|
| ATG17 | pexophagy: decreased Reporter: Pot1p | classical genetics | null Allele: atg17-Δ | Other | Cheong H, et al. (2005) PMID:15901835 | ||
| EGD1 | pexophagy: decreased | classical genetics | null Allele: egd1-Δ | S288C | Temperature: glycerol-containing Details: partial reduction in pexophagy compared to wt in glycerol grown cells at 72 hours; assayed using Pot1-mCherry, a peroxisomal matrix marker that is transported to the vacuole where it is processed during pexophagy; free mCherry signals are reduced to 54% of wt levels, as quantitated by western blot | Tian Y and Okamoto K (2024) PMID:38177147 | |
| EGD2 | pexophagy: decreased | classical genetics | null Allele: egd2-Δ | S288C | Temperature: glycerol-containing Details: partial reduction in pexophagy compared to wt in glycerol grown cells at 72 hours; assayed using Pot1-mCherry, a peroxisomal matrix marker that is transported to the vacuole where it is processed during pexophagy; free mCherry signals are reduced to 68% of wt levels, as quantitated by western blot | Tian Y and Okamoto K (2024) PMID:38177147 | |
| RAS2 | pexophagy: decreased | classical genetics | activation Allele: RAS2-val19 G19V; impaired GTPase activity; dominant allele locked in the activated state; analogous to G12V in oncogenic forms of human Ras | S288C | Treatment: glucose starvation and rapamycin treatment | Boutouja F and Platta HW (2020) PMID:33202661 | |
| SEC15 | pexophagy: decreased | classical genetics | conditional Allele: sec15-1 | Other | Media: nitrogen starvation Temperature: elevated temperature, 37 °C Details: reduction in pexophagy based on decreased accumulation of free GFP in cells expressing Pot1-GFP after incubation overnight in oleate-containing media followed by transfer to nitrogen-starvation media at the non-permissive temperature | Singh S, et al. (2019) PMID:31103773 | |
| TPS1 | pexophagy: decreased | classical genetics | null Allele: tps1-Δ | S288C | Media: glucose-containing nitrogen starvation media Details: defect in pexophagy, measured as a reduction in the processing of Pex11-GFP under nitrogen starvation conditions | Kim B, et al. (2021) PMID:32240040 | |
| TPS2 | pexophagy: decreased | classical genetics | null Allele: tps2-Δ | S288C | Media: glucose-containing nitrogen starvation media Details: defect in pexophagy, measured as a reduction in the processing of Pex11-GFP under nitrogen starvation conditions | Kim B, et al. (2021) PMID:32240040 |