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| Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|---|
| ABP140 | RNA modification: absent Reporter: tRNA-Thr | classical genetics | null Allele: abp140-Δ | S288C | Details: 3-methylcytidine (m3C) modification of residue 32 in the anticodon loop of tRNA-Thr(IGU) is lacking | D'Silva S, et al. (2011) PMID:21518804 | |
| ABP140 | RNA modification: absent Reporter: tRNA-Thr | classical genetics | null Allele: abp140-Δ | S288C | Details: loss of 3-methylcytidine (m3C) modification on tRNAs (tRNA-Thr1 and tRNA Ser1) | Noma A, et al. (2011) PMID:21518805 | |
| BUD32 | RNA modification: absent Reporter: tRNA-Ile | classical genetics | null Allele: bud32-Δ | W303 | Details: tRNA-Ile and other tRNAs that decode ANN codons lack t6A modification | Srinivasan M, et al. (2011) PMID:21183954 | |
| HRR25 | RNA modification: absent Reporter: tRNA killer eclipse assay | classical genetics | null Allele: hrr25-Δ | W303 | Details: abnormal content of modified 5-methoxycarbonylmethyluridine, 5-methoxycarbonylmethyl-2-thiouridine, and 2-thiouridine in total tRNA | Huang B, et al. (2008) PMID:18755837 | |
| IME4 | RNA modification: absent Reporter: mRNA | homozygous diploid | null Allele: ime4-Δ | SK1 | Phase: pre-meiotic G2 Details: N6-methyladenosine (m6A) modified mRNA in pre-meiotic G2 phase cells is absent | Agarwala SD, et al. (2012) PMID:22685417 | |
| IME4 | RNA modification: absent Reporter: mRNA | homozygous diploid | null Allele: ime4-Δ | SK1 | Media: sporulation Phase: early meiosis Details: severe reduction in N6-methyladenosine (m6A) methylation of mRNA in early meiotic cells relative to that observed in wt cells, as determined by LC-MS | Ensinck I, et al. (2023) PMID:37490041 | |
| IME4 | RNA modification: absent Reporter: mRNA | homozygous diploid | null Allele: ime4-cat D348A, W351A; highly conserved methyltransferase domain motif IV catalytic residues mutated; lacks methyltransferase activity and blocks meiosis | SK1 | Media: sporulation Phase: early meiosis Details: large reduction in N6-methyladenosine (m6A) methylation of mRNA in early meiotic cells relative to that observed in wt cells, as determined by LC-MS | Ensinck I, et al. (2023) PMID:37490041 | |
| IRE1 | RNA modification: absent Reporter: Hac1i mRNA spliced HAC1 mRNA | classical genetics | null Allele: ire1-Δ | S288C | 6 mM 1,4-dithiothreitol | Details: HAC1 mRNA splicing is absent in the null mutant treated with ER-stress inducer DTT and in the presence of Htt103Q (Huntingtin protein containing 103 polyglutamine repeats) | Das E, et al. (2023) PMID:36757110 |
| KAE1 | RNA modification: absent Reporter: tRNA-Ile | classical genetics | null Allele: kae1-Δ | W303 | Details: tRNA-Ile and other tRNAs that decode ANN codons lack t6A modification | Srinivasan M, et al. (2011) PMID:21183954 | |
| KAE1 | RNA modification: absent Reporter: tRNA-Ile | classical genetics | reduction of function Allele: kae1-H141A,H145A mutations predicted to abolish metal binding and ATPase activity based on similarity to M. jannaschii ortholog | W303 | Details: tRNA-Ile and other tRNAs that decode ANN codons lack t6A modification | Srinivasan M, et al. (2011) PMID:21183954 |