YRM1 / YOR172W Overview


Standard Name
YRM1 1
Systematic Name
YOR172W
SGD ID
SGD:S000005698
Feature Type
ORF , Verified
Description
Zinc finger transcription factor involved in multidrug resistance; Zn(2)-Cys(6) zinc finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes 1
Name Description
Yeast Reveromycin resistance Modulator 1
Comparative Info
Sequence Details

Sequence

The S. cerevisiae Reference Genome sequence is derived from laboratory strain S288C. Download DNA or protein sequence, view genomic context and coordinates. Click "Sequence Details" to view all sequence information for this locus, including that for other strains.


Protein Details

Protein

Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein.


Length (a.a.)
786
Mol. Weight (Da)
91084.3
Isoelectric Point
7.26
Median Abundance (molecules/cell)
267 +/- 143

Alleles

Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results. Click "YeastMine" to view all alleles in YeastMine.


View all YRM1 alleles in SGD search | YeastMine

Gene Ontology Details

Gene Ontology

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes.


Summary
Sequence-specific DNA binding transcription factor that regulates transcription by RNA polymerase II

View computational annotations

Molecular Function

Manually Curated

Biological Process

Manually Curated

Cellular Component

Manually Curated
Phenotype Details

Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided. Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.


Summary
Non-essential gene; overexpression in haploids impairs vegetative growth, increases resistance to TOR inhibitor rapamycin; overexpression in diploids enhances pseudohyphal growth; reduced function increases resistance to carcinogen 4-nitroquinoline N-oxide and antibiotic oligomycin; null mutants exhibit abnormal vacuolar morphology, increased sensitivity to the carcinogens benzo[a]pyrene and dieldrin, and to protein synthesis inbibitor cycloheximide
Interaction Details

Interaction

Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization.


44 total interactions for 39 unique genes

Physical Interactions

  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 8
  • Protein-RNA: 1

Genetic Interactions

  • Dosage Lethality: 4
  • Negative Genetic: 20
  • Positive Genetic: 4
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 1
Regulation Details

Regulation

The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. This evidence includes data generated through high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus.


Summary
YRM1 encodes a transcription factor that is a member of the C6 zinc finger class, containing a DNA binding domain also known as the Zn2Cys6 binuclear zinc cluster or zinc knuckle. Yrm1p can function as a transcriptional activator for genes involved in multidrug resistance, but apparently is functional only in the absence of its paralog YRR1. Promoter binding by Yrm1p is not observed in wild type, but in a yrr1 mutant strain, Yrm1p binds to the promoters of a set of genes overlapping with, but not identical to, Yrr1p targets. This suggests that interaction between Yrm1p and Yrr1p may abolish the DNA-binding activity of Yrm1p. Conversely, overproduction of Yrm1p reduces the transcriptional activation activity of Yrr1p.
Regulators
5
Targets
0
Expression Details

Expression

Expression data are derived from records contained in the Gene Expression Omnibus (GEO), and are first log2 transformed and normalized. Referenced datasets may contain one or more condition(s), and as a result there may be a greater number of conditions than datasets represented in a single clickable histogram bar. The histogram division at 0.0 separates the down-regulated (green) conditions and datasets from those that are up-regulated (red). Click "Expression Details" to view all expression annotations and details for this locus, including a visualization of genes that share a similar expression pattern.


Literature Details

Literature

All manually curated literature for the specified gene, organized into topics according to their relevance to the gene (Primary Literature, Additional Literature, or Review). Click "Literature Details" to view all literature information for this locus, including shared literature between genes.


Primary
8
Additional
18
Reviews
7

Resources