phosphorylation of RNA polymerase II C-terminal domain

Gene Ontology Term: phosphorylation of RNA polymerase II C-terminal domain

GO ID: GO:0070816
Aspect: Biological Process
Description: The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex.
Synonyms: CTD domain phosphorylation of RNA polymerase II, generation of hyperphosphorylated CTD of RNA polymerase II, generation of II(0) form of RNA polymerase II, hyperphosphorylation of RNA polymerase II C-terminal domain

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Annotations

Manually Curated 2 entries for 2 genes

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Gene/Complex	Qualifier	Gene Ontology Term	Annotation Extension	Evidence	Source	Assigned On	Reference
General transcription factor TFIIH complex	involved in	phosphorylation of RNA polymerase II C-terminal domain		IDA	ComplexPortal	2017-04-12	Kim M, et al. (2009) PMID:19679665
Carboxy-terminal domain protein kinase complex	involved in	phosphorylation of RNA polymerase II C-terminal domain		IDA	ComplexPortal	2014-10-16	Hautbergue G and Goguel V (2001) PMID:11118453

Gene/Complex

Qualifier

Gene Ontology Term

Annotation Extension

Evidence

Source

Assigned On

Reference

General transcription factor TFIIH complex

involved in

phosphorylation of RNA polymerase II C-terminal domain

IDA