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  • Gene Ontology Term: phosphorylation of RNA polymerase II C-terminal domain
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Gene Ontology Term: phosphorylation of RNA polymerase II C-terminal domain


GO ID
GO:0070816
Aspect
Biological Process
Description
The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex.
Synonyms
CTD domain phosphorylation of RNA polymerase II, generation of hyperphosphorylated CTD of RNA polymerase II, generation of II(0) form of RNA polymerase II, hyperphosphorylation of RNA polymerase II C-terminal domain
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Ontology Diagram


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Manually Curated 2 entries for 2 genes

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Gene/ComplexQualifierGene Ontology TermAnnotation ExtensionEvidenceSourceAssigned OnReference
General transcription factor TFIIH complexinvolved inphosphorylation of RNA polymerase II C-terminal domainIDAComplexPortal2017-04-12Kim M, et al. (2009) PMID:19679665
Carboxy-terminal domain protein kinase complexinvolved inphosphorylation of RNA polymerase II C-terminal domainIDAComplexPortal2014-10-16Hautbergue G and Goguel V (2001) PMID:11118453
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High-throughput 0 entries for 0 genes

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Evidence ID Analyze ID Gene/Complex Systematic Name/Complex Accession Qualifier Gene Ontology Term ID Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference
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Computational 0 entries for 0 genes

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Evidence ID Analyze ID Gene/Complex Systematic Name/Complex Accession Qualifier Gene Ontology Term ID Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference
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