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    Gene Ontology Term: branched-chain 2-oxo acid dehydrogenase activity


    GO ID
    GO:0003863
    Aspect
    Molecular Function
    Description
    Catalysis of the reaction: N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + 3-methyl-2-oxobutanoate + H+ = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + CO2. Also acts on 4-methyl-2-oxopentanoate and (S)-3-methyl-2-oxopentanoate, so that it acts on the 2-oxo acids that derive from the action of transaminases on valine, leucine and isoleucine.
    Synonyms
    2-oxoisocaproate dehydrogenase activity, 2-oxoisovalerate (lipoate) dehydrogenase activity, 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity, 3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating), 3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity, alpha-keto-alpha-methylvalerate dehydrogenase activity, alpha-ketoisocaproate dehydrogenase activity, alpha-ketoisocaproic dehydrogenase activity, alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity, alpha-ketoisovalerate dehydrogenase activity, alpha-oxoisocaproate dehydrogenase activity, BCKDH activity, BCOAD activity, branched chain keto acid dehydrogenase activity, branched-chain (-2-oxoacid) dehydrogenase (BCD) activity, branched-chain 2-keto acid dehydrogenase activity, branched-chain 2-oxo acid dehydrogenase activity, branched-chain alpha-keto acid dehydrogenase activity, branched-chain alpha-oxo acid dehydrogenase activity, branched-chain keto acid dehydrogenase activity, branched-chain ketoacid dehydrogenase activity, dehydrogenase, 2-oxoisovalerate (lipoate) activity, dehydrogenase, branched chain alpha-keto acid activity, 2-oxoisocaproate dehydrogenase activity, 2-oxoisovalerate (lipoate) dehydrogenase activity, 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity, 3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating), 3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity, alpha-keto-alpha-methylvalerate dehydrogenase activity, alpha-ketoisocaproate dehydrogenase activity, alpha-ketoisocaproic dehydrogenase activity, alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity, alpha-ketoisovalerate dehydrogenase activity, alpha-oxoisocaproate dehydrogenase activity, dehydrogenase, 2-oxoisovalerate (lipoate) activity, alpha-ketoacid dehydrogenase activity, 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
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    Evidence ID Analyze ID Gene/Complex Systematic Name/Complex Accession Qualifier Gene Ontology Term ID Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference
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    Evidence ID Analyze ID Gene/Complex Systematic Name/Complex Accession Qualifier Gene Ontology Term ID Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference
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    Computational

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    Evidence ID Analyze ID Gene/Complex Systematic Name/Complex Accession Qualifier Gene Ontology Term ID Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference
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