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  • Dataset: Endoplasmic reticulum–mitochondria junction is required for iron homeostasis
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  • Summary
  • Conditions

Dataset: Endoplasmic reticulum–mitochondria junction is required for iron homeostasis

External ID
GSE99499
Reference
Xue Y, et al. (2017)
Channels
1
Conditions
12
Description
The Endoplasmic Reticulum–Mitochondria Encounter Structure (ERMES) is a protein complex that tethers the two organelles and creates the physical basis for communication between them. ERMES functions in lipid and calcium exchange between the ER and mitochondria, mitochondrial protein import and maintenance of mitochondrial morphology and genome. Here we report that ERMES is also required for iron homeostasis. Loss of ERMES components activates an Aft1-dependent iron deficiency response even in iron-replete conditions, leading to accumulation of excess iron inside the cell. This function is independent of ERMES known roles in calcium regulation, phospholipid biosynthesis or mitochondrial biology. A mutation in the vacuolar protein sorting 13 (VPS13) gene that rescues the glycolytic phenotype of ERMES mutants suppresses the iron deficiency response and iron accumulation. Our study reveals that proper communication between the ER and mitochondria is required for appropriate maintenance of cellular iron levels.
Categories
metal or metalloid ion utilization, organelles, biogenesis, structure, and function

Conditions

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

ConditionExternal ID
Aft1-1upGSM2644875
mdm34del_rep1GSM2644868
mmm1del_rep1GSM2644867
mmm1del_rep2GSM2644873
sam37delGSM2644876
VPS13-D716HGSM2644872
VPS13-D716H_mmm1delGSM2644874
VPS13-D716H_sam37delGSM2644877
WT_celanYPDGSM2644869
WT_celanYPD_BPSGSM2644870
Showing 1 to 10 of 12 entries
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