Molecular basis of complex heritability in natural genotype-to-phenotype relationships

Dataset: Molecular basis of complex heritability in natural genotype-to-phenotype relationships

External ID: GSE123702
Channels: 1
Conditions: 18
Description: The intrinsic complexity of quantitative traits was evident even before the molecular nature of the gene was understood. Yet we still lack a detailed molecular understanding of complex heritability. Here we alleviated statistical roadblocks to high-resolution genetic mapping by using an inbred population of diploid yeast with very low linkage disequilibrium and more individuals than segregating polymorphisms. We mapped over 18,000 quantitative trait loci, resolving more than 3,300 to single nucleotides. This allowed us to explore the molecular origins of complexity, hybrid vigor, pleiotropy, and gene ´ environment interactions and to rigorously estimate the distribution of fitness effects of natural genetic variation. Our results describe a comprehensive, high-resolution genotype-to-phenotype map and define general principles underlying the complexity of heredity.
Categories: environmental-sensing, evolution

Conditions

Type a keyword (examples: “BAS1”, “zinc”) into this box to filter for those rows within the table that contain the keyword. Type in more than one keyword to find rows containing all keywords: for instance, “BAS1 37” returns rows that contain both "BAS1" and "37". To remove the filter, simply delete the text from the box.

Condition	External ID
RM-SEtOH-1	GSM3509869
RM-Sgly-1	GSM3509863
RM-SD-1	GSM3509857
YJM-SD-1	GSM3509860
YJM-Sgly-1	GSM3509866
YJM-SEtOH-1	GSM3509872
RM-SEtOH-2	GSM3509870
RM-Sgly-2	GSM3509864
RM-SD-2	GSM3509858
YJM-SD-2	GSM3509861

Condition

External ID

RM-SEtOH-1

RM-Sgly-1

RM-SD-1

YJM-SD-1

YJM-Sgly-1