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    Complex: TOM40 mitochondrial outer membrane translocase holocomplex

    Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.


    Curated by
    IntAct
    ComplexAc
    CPX-474
    Systematic Name
    TOM5:TOM6:TOM7:TOM20:TOM22:TOM40:TOM70
    SGD ID
    SGD:S000218019
    Aliases
    Mitochondrial outer membrane translocase holocomplex ; Preprotein translocase of the outer mitochondrial membrane ; TOM holocomplex

    Complex Diagram

    This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.


    PDB Structure

    When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.


    6UCU 6UCU 6UCV 6UCV

    Subunits

    This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.


    Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

    Subunit Description Stoichiometry

    Gene Ontology

    Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.


      Biological Process
    • protein insertion into mitochondrial outer membrane
      Cellular Component
    • mitochondrial outer membrane
    • mitochondrial outer membrane translocase complex

    Shared Annotations

    This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.


    References

    List of references used specifically to curate the information on this page.


    • Araiso Y, et al. (2019) Structure of the mitochondrial import gate reveals distinct preprotein paths. Nature 575(7782):395-401 PMID: 31600774
      • SGD Paper
      • DOI full text
      • PubMed
    • Tucker K and Park E (2019) Cryo-EM structure of the mitochondrial protein-import channel TOM complex at near-atomic resolution. Nat Struct Mol Biol 26(12):1158-1166 PMID: 31740857
      • SGD Paper
      • DOI full text
      • PubMed
    • Endo T, et al. (2003) Functional cooperation and separation of translocators in protein import into mitochondria, the double-membrane bounded organelles. J Cell Sci 116(Pt 16): 3259-67. PMID: 12857785
      • SGD Paper
      • DOI full text
      • PubMed

    External Identifiers


    EMDB: EMD-20728 | EMDB: EMD-20729
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