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    Complex: Eukaryotic translation initiation factor 4F complex, variant TIF4631

    Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.


    Curated by
    IntAct
    ComplexAc
    CPX-430
    Systematic Name
    CDC33:[TIF1:TIF2]:TIF4631
    SGD ID
    SGD:S000217629
    Aliases
    IF-4F complex ; IF4F complex ; eIF-4F complex ; eIF4F complex

    Complex Diagram

    This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.


    PDB Structure

    When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.


    1RF8 1RF8 2VSO 2VSO 2VSX 2VSX

    Subunits

    This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.


    Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

    Subunit Description Stoichiometry

    Gene Ontology

    Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.


      Molecular Function
    • ATP binding
    • RNA 7-methylguanosine cap binding
    • RNA helicase activity
    • RNA-dependent ATPase activity
    • translation initiation factor activity
      Biological Process
    • regulation of translational initiation
      Cellular Component
    • eukaryotic translation initiation factor 4F complex
    • ribosome

    Shared Annotations

    This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.


    References

    List of references used specifically to curate the information on this page.


    • Schütz P, et al. (2008) Crystal structure of the yeast eIF4A-eIF4G complex: an RNA-helicase controlled by protein-protein interactions. Proc Natl Acad Sci U S A 105(28):9564-9 PMID: 18606994
      • SGD Paper
      • DOI full text
      • PMC full text
      • PubMed
    • Gross JD, et al. (2003) Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E. Cell 115(6):739-50 PMID: 14675538
      • SGD Paper
      • DOI full text
      • PubMed
    • Blum S, et al. (1992) ATP hydrolysis by initiation factor 4A is required for translation initiation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 89(16):7664-8 PMID: 1502180
      • SGD Paper
      • DOI full text
      • PMC full text
      • PubMed

    External Identifiers


    IntEnz: 3.6.4.13
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