Complex: Eukaryotic translation initiation factor 4F complex, variant TIF4631
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-430
- Systematic Name
- CDC33:[TIF1:TIF2]:TIF4631
- SGD ID
- SGD:S000217629
- Aliases
- IF-4F complex ; IF4F complex ; eIF-4F complex ; eIF4F complex
- Description
- Binds the 5-prime cap of messenger RNAs to recruit mRNA to the ribosome during translation initiation. During cap-dependent translation, eIF4G1 (TIF4631) brings the 5' end of the mRNA in proximity with the helicase eIF4A (TIF1,TIF2) through interactions with eIF4E (CDC33). Facilitates 48S pre-initiation complex formation through interaction with eIF3 (CPX-1831) in the 43S pre-initiation complex. The relatively weak helicase activity of eIF4A is presumed to be required for unwinding mRNA secondary structures. The poly(A) binding protein PAB1 can bind to eIF4G1 act to stimulate cap-dependent translation initiation, even in the absence of a poly(A) tail.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables ATP binding (BSR)
- enables ATP-dependent activity, acting on RNA (BSR)
- enables RNA 7-methylguanosine cap binding (BSR)
- enables RNA helicase activity (BSR)
- enables translation initiation factor activity (BSR)
- Biological Process
-
- involved in regulation of translational initiation (BSR)
- Cellular Component
-
- located in eukaryotic translation initiation factor 4F complex (BSR)
- located in ribosome (BSR)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Schütz P, et al. (2008) Crystal structure of the yeast eIF4A-eIF4G complex: an RNA-helicase controlled by protein-protein interactions. Proc Natl Acad Sci U S A 105(28):9564-9 PMID: 18606994
- Gross JD, et al. (2003) Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E. Cell 115(6):739-50 PMID: 14675538
- Blum S, et al. (1992) ATP hydrolysis by initiation factor 4A is required for translation initiation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 89(16):7664-8 PMID: 1502180
Resources
IntAct | PDB:1RF8 | PDB:2VSO | PDB:2VSX ... Show all Show fewer