Complex: PAN2-PAN3 mRNA deadenylation complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- SGD
- ComplexAc
- CPX-3294
- Systematic Name
- PAN2:2xPAN3
- SGD ID
- SGD:S000217799
- Aliases
- PAN deadenylation complex ; poly(A)-specific nuclease complex
- Description
- A poly(A)-specific 3' exoribonuclease required to regulate Poly(A) tails added to mRNA co-transcriptionally and which are required for the export of mature mRNAs to the cytoplasm The complex is responsible for the poly(A) trimming of the tail length to a transcript specific size which regulates translation repression and mRNA decay.The complex is non-essential, but its deletion results in increased poly(A)-tail length.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
PDB Structure
When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.
| 4XR7 |
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables poly(A)-specific ribonuclease activity (IDA)
- Biological Process
-
- involved in nuclear-transcribed mRNA poly(A) tail shortening (IDA)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Passmore LA and Coller J (2022) Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression. Nat Rev Mol Cell Biol 23(2):93-106 PMID: 34594027
- Schäfer IB, et al. (2014) The structure of the Pan2-Pan3 core complex reveals cross-talk between deadenylase and pseudokinase. Nat Struct Mol Biol 21(7):591-8 PMID: 24880344
- Wahle E and Winkler GS (2013) RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3 complexes. Biochim Biophys Acta 1829(6-7):561-70 PMID: 23337855
- Schwede A, et al. (2009) The role of deadenylation in the degradation of unstable mRNAs in trypanosomes. Nucleic Acids Res 37(16):5511-28 PMID: 19596809
- Brown CE, et al. (1996) PAN3 encodes a subunit of the Pab1p-dependent poly(A) nuclease in Saccharomyces cerevisiae. Mol Cell Biol 16(10):5744-53 PMID: 8816488
Resources
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