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Complex: COPII vesicle coat complex

Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.

Curated by
IntAct
ComplexAc
CPX-2523
Systematic Name
SAR1:SEC13:SEC23:SEC24:2xSEC31
SGD ID
SGD:S000218116
Aliases
COPII complex ; Cytoplasmic coat protein complex II
Description
Mediates formation of the membrane vesicles that export newly synthesised proteins from the endoplasmic reticulum. Upon exchange of GDP for GTP (catalysed by SEC12), SAR1 exposes an N-terminal amphipathic helix that inserts into the outer ER membrane leaflet, promoting curvature. SAR1 recruits SEC23/24 to the membrane to form the inner layer of the COPII coat. SEC24 binds transport cargo while SEC23 interacts with SAR1 and recruits the outer COPII components (SEC13/31) that form a cage around the vesicle by self-assembling into a polyhedron. SEC16 may also be required for proper COPII coat assembly but its role has not been clearly defined.

Complex Diagram

This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.

PDB Structure

When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.

1M2O 1M2O 1M2V 1M2V 2PM6 2PM6 2PM7 2PM7 2PM9 2PM9 2QTV 2QTV 3MZL 3MZL 4BZI 4BZI 4BZJ 4BZJ 4BZK 4BZK

Subunits

This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.

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Subunit Description Stoichiometry

Gene Ontology

Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.

Shared Annotations

This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.

External Identifiers

EMDB: 2428 | EMDB: 2429 | EMDB: 2430 | EMDB: 2431 | EMDB: 2432

Resources

IntAct | ModelArchive | PDB:1M2O | PDB:1M2V | PDB:2PM6 | PDB:2PM7 | PDB:2PM9 | PDB:2QTV | PDB:3MZL | PDB:4BZI | PDB:4BZJ ... Show all