Complex: DNA polymerase delta complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-2101
- Systematic Name
- POL3:POL31:POL32
- SGD ID
- SGD:S000218008
- Aliases
- DNA polymerase delta heterotrimer ; Pol delta
- Description
- Believed to be the major polymerase for the elongation of both leading and lagging strands of chromosomal DNA in eukaryotic cells. Required for Okazaki fragment maturation together with Fen1 and proliferating cell nuclear antigen (PCNA). The 3'-5'-exonuclease activity of DNA polymerase delta is important for this process. Also involved in telomerase-mediated telomere addition and participates in several DNA repair pathways
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
PDB Structure
When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.
| 6P1H |
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables DNA-directed DNA polymerase activity (IDA)
- enables double-stranded DNA binding (IPI)
- Biological Process
-
- involved in DNA metabolic process (IDA)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Jain R, et al. (2019) Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ holoenzyme. Nat Struct Mol Biol 26(10):955-962 PMID: 31582849
Resources
IntAct | ModelArchive | PDB:6P1H ... Show all Show fewer