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Complex: CCR4-NOT mRNA deadenylase complex

Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.

Curated by
IntAct
ComplexAc
CPX-1800
Systematic Name
CAF40:CAF130:CCR4:CDC36:CDC39:MOT2:NOT3:NOT5:POP2
SGD ID
SGD:S000217975
Description
Major cellular mRNA deadenylase complex, removing polyA tails that protect transcripts from degradation and promotes translation in the cytoplasm. The complex is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation, and general transcription regulation, potentially by promoting the resumption of elongation of arrested RNAPII when it encounters transcriptional blocks in vivo.

Complex Diagram

This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.

PDB Structure

When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.

4B8A 4B8A 4B8C 4B8C 4BY6 4BY6 4CV5 4CV5 5AJD 5AJD

Subunits

This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.

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Subunit Description Stoichiometry

Gene Ontology

Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.

Shared Annotations

This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.

References

List of references used specifically to curate the information on this page.

External Identifiers

EMDB: EMD-1901 | IntEnz: 3.1.13.4

Resources

IntAct | ModelArchive | PDB:4B8A | PDB:4B8C | PDB:4BY6 | PDB:4CV5 | PDB:5AJD