Complex: THO complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-1792
- Systematic Name
- HPR1:MFT1:TEX1:THO2:THP2
- SGD ID
- SGD:S000217973
- Aliases
- THO transcription elongation complex
- Description
- Functions in the formation and nuclear export of translation-competent messenger ribonucleoprotein particles. Functions at the interface between transcription and mRNA export via its interaction with SUB2 in the TREX complex (CPX-1793). Recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase. The inclusion o Tex1 in this complex is debated in the literature.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
PDB Structure
When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.
| 7V2W |
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
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Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables DNA binding (IDA)
- Biological Process
-
- acts upstream of or within DNA-templated transcription elongation (IMP)
- involved in mRNA export from nucleus (BSR)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Beauvais V, et al. (2023) Tho2 is critical for the recruitment of Rrp6 to chromatin in response to perturbed mRNP biogenesis. RNA 30(1):89-98 PMID: 37914399
- Chen C, et al. (2021) Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex. Sci Bull (Beijing) 66(23): 2347-2352. PMID: 36654119
- Peña A, et al. (2012) Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor. EMBO J 31(6):1605-16 PMID: 22314234
- Chávez S, et al. (2000) A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. EMBO J 19(21):5824-34 PMID: 11060033
Resources
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