Complex: General transcription factor TFIIIC complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-1656
- Systematic Name
- TFC1:TFC3:TFC4:TFC6:TFC7:TFC8
- SGD ID
- SGD:S000218041
- Aliases
- TFIIIC complex
- Description
- Transcription factor required for Pol III transcription complex assembly. Mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Assembles the initiation complex TFIIIB-TFIIIC-tDNA upstream of the transcription start site, which is sufficient for RNA polymerase III (CPX-2660) recruitment and function.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables DNA binding (BSR)
- enables RNA polymerase III general transcription initiation factor activity (BSR)
- enables RNA polymerase III transcription regulatory region sequence-specific DNA binding (BSR)
- Biological Process
-
- involved in transcription initiation at RNA polymerase III promoter (BSR)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Vorländer MK, et al. (2020) Structure of the TFIIIC subcomplex τA provides insights into RNA polymerase III pre-initiation complex formation. Nat Commun 11(1):4905 PMID: 32999288
- Ciesla M, et al. (2018) Function of TFIIIC, RNA polymerase III initiation factor, in activation and repression of tRNA gene transcription. Nucleic Acids Res 46(18):9444-9455 PMID: 30053100
- Male G, et al. (2015) Architecture of TFIIIC and its role in RNA polymerase III pre-initiation complex assembly. Nat Commun 6:7387 PMID: 26060179
- Arrebola R, et al. (1998) Tau91, an essential subunit of yeast transcription factor IIIC, cooperates with tau138 in DNA binding. Mol Cell Biol 18(1):1-9 PMID: 9418847
Resources
IntAct | ModelArchive | PDB:2J04 | PDB:6YJ6 ... Show all Show fewer