Complex: General transcription factor complex TFIID
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-1642
- Systematic Name
- TAF1:TAF2:TAF3:2xTAF4:2xTAF5:2xTAF6:TAF7:TAF8:2xTAF9:2xTAF10:TAF11:2xTAF12:TAF13:3xTAF14:TBP
- SGD ID
- SGD:S000217963
- Aliases
- Transcription factor complex IID
- Description
- General transcription factor complex that acts as the primary core promoter recognition factor in the initiation of RNA polymerase II (Pol II)-dependent transcription. The TBP subunit of TFIID recognizes and binds to the TATA box (if present), while TAF1 and TAF2 interact with the Initiator element (Inr), and TAF1 and the TAF6-TAF9 module recognizes the downstream core promoter element (DPE). Other core promoter elements, such as the motif ten element (MTE), may also be involved. Binding of the general transcription factor complex TFIIA (CPX-1633) enhances binding of TFIID to the core promoter and nucleates pre-initiation complex (PIC) assembly. Following recruitment of TFIIA to TFIID, TFIIB, TFIIF, Pol II, TFIIE (CPX-1658) and TFIIH are successively assembled at the core promoter, allowing the PIC to initiate Pol II transcription.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
PDB Structure
When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.
| 4OY2 |
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables core promoter sequence-specific DNA binding (IDA)
- Biological Process
-
- involved in positive regulation of transcription by RNA polymerase II (IDA)
- Cellular Component
-
- located in nucleus (BSR)
- located in transcription factor TFIID complex (IPI)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Leurent C, et al. (2002) Mapping histone fold TAFs within yeast TFIID. EMBO J 21(13):3424-33 PMID: 12093743
Resources
IntAct | ModelArchive | PDB:4OY2 ... Show all Show fewer