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  • Author: Hampton RY
  • References

Author: Hampton RY


References 45 references


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  • Wangeline MA and Hampton RY (2021) An autonomous, but INSIG-modulated, role for the sterol sensing domain in mallostery-regulated ERAD of yeast HMG-CoA reductase. J Biol Chem 296:100063 PMID:33184059
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  • Neal S, et al. (2018) The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins. Mol Cell 69(2):306-320.e4 PMID:29351849
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  • Wangeline MA and Hampton RY (2018) "Mallostery"-ligand-dependent protein misfolding enables physiological regulation by ERAD. J Biol Chem 293(38):14937-14950 PMID:30018140
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  • Vashistha N, et al. (2016) Direct and essential function for Hrd3 in ER-associated degradation. Proc Natl Acad Sci U S A 113(21):5934-9 PMID:27170191
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  • Theesfeld CL and Hampton RY (2013) Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast. J Biol Chem 288(12):8519-8530 PMID:23306196
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  • Theesfeld CL, et al. (2011) The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2. J Biol Chem 286(30):26298-307 PMID:21628456
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  • Carroll SM and Hampton RY (2010) Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase. J Biol Chem 285(8):5146-56 PMID:19940128
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  • Heck JW, et al. (2010) Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1. Proc Natl Acad Sci U S A 107(3):1106-11 PMID:20080635
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  • Garza RM, et al. (2009) Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast. J Biol Chem 284(51):35368-80 PMID:19776008
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  • Garza RM, et al. (2009) In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase. J Biol Chem 284(22):14710-22 PMID:19324879
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  • Hampton RY and Garza RM (2009) Protein quality control as a strategy for cellular regulation: lessons from ubiquitin-mediated regulation of the sterol pathway. Chem Rev 109(4):1561-74 PMID:19243134
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  • Sato BK, et al. (2009) Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase. Mol Cell 34(2):212-22 PMID:19394298
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  • Bazirgan OA and Hampton RY (2008) Cue1p is an activator of Ubc7p E2 activity in vitro and in vivo. J Biol Chem 283(19):12797-810 PMID:18321851
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  • Federovitch CM, et al. (2008) Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae. Mol Biol Cell 19(10):4506-20 PMID:18667535
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  • Sato BK and Hampton RY (2006) Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis. Yeast 23(14-15):1053-64 PMID:17083136
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  • Bazirgan OA and Hampton RY (2005) Cdc48-Ufd2-Rad23: the road less ubiquitinated? Nat Cell Biol 7(3):207-9 PMID:15738968
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  • Hampton RY (2003) IRE1: a role in UPREgulation of ER degradation. Dev Cell 4(2):144-6 PMID:12586055
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  • Bays NW and Hampton RY (2002) Cdc48-Ufd1-Npl4: stuck in the middle with Ub. Curr Biol 12(10):R366-71 PMID:12015140
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  • Hampton RY (2002) ER-associated degradation in protein quality control and cellular regulation. Curr Opin Cell Biol 14(4):476-82 PMID:12383799
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  • Gardner RG and Hampton RY (1999) A 'distributed degron' allows regulated entry into the ER degradation pathway. EMBO J 18(21):5994-6004 PMID:10545111
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  • Gardner RG and Hampton RY (1999) A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes. J Biol Chem 274(44):31671-8 PMID:10531376
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