Mutation leads to reduced eIF2α phosphorylation, suggesting that the Asp56 residue is required for full Gcn2p activation; D56A substitution may impair actin-Yih1p interaction, increasing amount of Yih1p available to inhibit Gcn2p
List of references used specifically to curate the information in Overview section.
Ramesh R, et al. (2021) Asp56 in actin is critical for the full activity of the amino acid starvation-responsive kinase Gcn2. FEBS Lett 595(14):1886-1901