Dosage-dependent lethal form of ubiquitin; lethal to UBI4-deficient cells but not to ubiquitin wild-type cells; allele carries four amino acid substitutions - S20F, A46S, L50P and I61T; expression in UBI4-deleted stress-sensitive strain results in increased generation time, delayed S phase, decreased levels of Cdc28p protein kinase; confers sensitivity towards heat and cycloheximide; negatively effects degradation of substrates of ubiquitin fusion degradation pathway
List of references used specifically to curate the information in Overview section.
Doshi A, et al. (2014) Functional characterization of dosage-dependent lethal mutation of ubiquitin in Saccharomyces cerevisiae. FEMS Yeast Res 14(7):1080-9