Mutation in Sir3p AAA+ domain that abrogates Sir3p silencing function; mutation is in extended loop of base subdomain that connects α-helix 4 to strand 3 of central β-sheet; abrogates in vitro interaction of Sir3p with Sir2p/Sir4p
List of references used specifically to curate the information in Overview section.
Samel A, et al. (2017) Variants of the Sir4 Coiled-Coil Domain Improve Binding to Sir3 for Heterochromatin Formation in Saccharomyces cerevisiae. G3 (Bethesda) 7(4):1117-1126