Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
26 entries for 14 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
---|---|---|---|---|---|---|---|
CSM4 | biofilm formation: increased | systematic mutation set | null Allele: csm4-Δ | S288C | Vandenbosch D, et al. (2013) PMID:24034557 | ||
CSM4 | chemical compound accumulation: increased | homozygous diploid | null Allele: csm4-Δ | S288C | cobalt(2+) | Treatment: cobalt dichloride, 1 mM Details: cobalt sensitive null mutant accumulates cobalt after treatment with CoCl2 for 12 hrs | Zhao YY, et al. (2020) PMID:31904504 |
CSM4 | competitive fitness: increased | competitive growth fitness profiling using complete deletion alleles | null Allele: csm4-Δ | S288C | Media: minimal medium Details: Relative fitness score: 1.018 | Breslow DK, et al. (2008) PMID:18622397 | |
CSM4 | haploinsufficient | heterozygous diploid, competitive growth genome-wide fitness profiling | null Allele: csm4-Δ | S288C | Media: turbidostat growth in FPM medium Details: Relative growth score: -0.0032 | Pir P, et al. (2012) PMID:22244311 | |
CSM4 | meiosis: abnormal | homozygous diploid, systematic mutation set Immunofluorescence of chromosome V | null Allele: csm4-Δ | SK1 | Details: Aberrant meiotic chromosome segregation | Rabitsch KP, et al. (2001) PMID:11470404 | |
CSM4 | meiosis: delayed | classical genetics | null Allele: csm4-Δ | SK1 | Kosaka H, et al. (2008) PMID:18818742 | ||
CSM4 | meiosis: delayed | classical genetics | null Allele: csm4-Δ | Other | Wanat JJ, et al. (2008) PMID:18818741 | ||
CSM4 | meiosis: delayed | homozygous diploid | null Allele: csm4-Δ | SK1 | Details: delay in meiosis I, based on SPB separation, compared to wt cells | Fan J, et al. (2020) PMID:32967926 | |
CSM4 | meiotic recombination: decreased | homozygous diploid | null Allele: csm4-Δ | SK1 | Details: 2 hr delay in homolog pairing and an ~ 10-fold reduction in the gene conversion rate at the ARG4 and HIS4 loci | Fan J, et al. (2020) PMID:32967926 | |
CSM4 | meiotic recombination: increased | classical genetics | null Allele: csm4-Δ | Other | Wanat JJ, et al. (2008) PMID:18818741 |
An interaction is defined as an experimentally observed physical or genetic interaction between two genes. There may be more than one row listed for the same interactor if the interaction between it and the given gene was observed in separate studies. All interactions listed in SGD are curated by BioGRID.
8 entries for 9 genesIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details about experiment type and any other genes involved in the interaction.
Interactor | Interactor | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Reference | |
---|---|---|---|---|---|---|---|---|---|---|
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | YCH1 | CSM4 | ych1-Δ, csm4-Δ | Positive Genetic | high-throughput | Bait-Hit | 0.1859 | 0.00159 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | SEC20 | CSM4 | sec20-1, csm4-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.139 | 0.03862 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | HYP2 | CSM4 | hyp2-2, csm4-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.1447 | 0.04647 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | TIM21 | CSM4 | tim21-Δ, csm4-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.1382 | 0.01191 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | ROF1 | CSM4 | yhr177w-Δ, csm4-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.285 | 0.0009156 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | YIR044C | CSM4 | yir044c-Δ, csm4-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.1209 | 0.000006268 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | SWC7 | CSM4 | swc7-Δ, csm4-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.1276 | 0.01124 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | HST3 | CSM4 | hst3-Δ, csm4-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.1268 | 0.03133 | Costanzo M, et al. (2016) PMID:27708008 |
This diagram displays up to the top 30 positive interactions (green), negative interactions (orange), and phenotypes (blue) that are shared between the given allele (black) and other alleles (purple). The shared interactions or phenotypes can be visualized separately using the radio button at the bottom of the graph.
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