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Reference: Wang S, et al. (2013) A peroxisome biogenesis deficiency prevents the binding of alpha-synuclein to lipid droplets in lipid-loaded yeast. Biochem Biophys Res Commun 438(2):452-6

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Abstract


Using a yeast model of Parkinson's disease, we found that alpha-synuclein (aS) binds to lipid droplets in lipid-loaded, wild-type yeast cells but not to lipid droplets in lipid-loaded, peroxisome-deficient cells (pex3?). Our analysis revealed that pex3? cells have both fewer lipid droplets and smaller lipid droplets than wild-type cells, and that the acyl chains of the phospholipids on the surface of the lipid droplets from pex3? cells are on average shorter (C16) than those (C18) on the surface of lipid droplets from wild-type cells. We propose that the shift to shorter (C18?C16) acyl chains contributes to the reduced binding of aS to lipid droplets in pex3? cells.

Reference Type
Journal Article
Authors
Wang S, Horn PJ, Liou LC, Muggeridge MI, Zhang Z, Chapman KD, Witt SN
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