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Reference: Bertini I, et al. (2011) High-resolution characterization of intrinsic disorder in proteins: expanding the suite of (13)C-detected NMR spectroscopy experiments to determine key observables. Chembiochem 12(15):2347-52

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Abstract


Order in disorder: The characterization of intrinsically disordered proteins by NMR spectroscopy is a necessity on the one hand and a continuous challenge on the other. We propose two experiments that provide diagnostic parameters to monitor the degree of unfolding of a polypeptide. The test was performed on the yeast Cox17 protein, known to gain its function through maturation from an intrinsically disordered state (see figure).

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Bertini I, Felli IC, Gonnelli L, Vasantha Kumar MV, Pierattelli R
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