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Reference: Ng NS, et al. (2013) The antimicrobial properties of some copper(II) and platinum(II) 1,10-phenanthroline complexes. Dalton Trans 42(9):3196-209

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Abstract


Copper(ii) (1(Cu)-21(Cu)) and previously established experimental anticancer platinum(ii) metallointercalator complexes (1(Pt)-16(Pt)) have been prepared and investigated for their antimicrobial properties. These complexes are of the general structure [M(I(L))(A(L))](2+) where I(L) represents functionalised 1,10-phenanthrolines (1(IL)-10(IL)), and A(L) represents 1,2-diaminoethane, 1S,2S- or 1R,2R-diaminocyclohexane. The structures of synthesised complexes were confirmed using a combination of elemental analysis, UV spectrometry, circular dichroism, (1)H and [(1)H-(195)Pt]-HMQC NMR, X-ray crystallography, and electrospray ionisation mass spectrometry and where appropriate. Crystallisation attempts yielded single crystals of [Cu(4-methyl-1,10-phenanthroline)(1R,2R-diaminocyclohexane)](ClO(4))(2) (4(Cu)), [Cu(5,6-dimethyl-1,10-phenanthroline)(1R,2R-diaminocyclohexane)(H(2)O)](ClO(4))(2 ).1.5H(2)O (10(Cu)) and [Cu(5,6-dimethyl-1,10-phenanthroline)(3)](ClO(4))(2).5,6-dimethyl-1,10-phenanthro line.2H(2)O (21(Cu)). Growth inhibition of liquid cultures of bacteria (Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa), and yeast (Saccharomyces cerevisiae) discerned the most antimicrobially potent metal complexes

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Ng NS, Leverett P, Hibbs DE, Yang Q, Bulanadi JC, Jie Wu M, Aldrich-Wright JR
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