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Reference: Taranukha D, et al. (2012) Co-regulation of polar mRNA transport and lifespan in budding yeast Saccharomyces cerevisiae. Cell Cycle 11(22):4275-80

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Abstract


Recent studies have uncovered the links between aging, rejuvenation and polar protein transport in the budding yeast Saccharomyces cerevisiae. Here, we examined a still unexplored possibility for co-regulation of polar mRNA transport and lifespan. To monitor the amount and distribution of mRNA-containing granules in mother and daughter cells, we used a fluorescent mRNA-labeling system, with MFA2 as a reporter gene. The results obtained showed that deletion of the selected longevity regulators in budding yeast had a significant impact on the polar mRNA transport. This included changes in the amount of mRNA-containing granules in cytoplasm, their aggregation and distribution between the mother and daughter cells. A significant negative correlation was found between strain-specific longevity, amount of granules and total fluorescent intensity both in mother and daughter cells. As indicated by the coefficient of determination, approximately 50-75% of variation in yeast lifespan could be attributed to the differences in polar mRNA transport.

Reference Type
Journal Article
Authors
Taranukha D, Budovsky A, Gobshtis N, Braiman A, Porat Z, Aronov S, Fraifeld VE
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