Reference: Kupiec M and Weisman R (2012) TOR links starvation responses to telomere length maintenance. Cell Cycle 11(12):2268-71

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Abstract


Telomeres are nucleoprotein structures that protect the ends of eukaryotic chromosomes and play important roles in ensuring the genome's integrity. Telomere length is maintained by complex mechanisms that ensure length homeostasis. Recent work has linked telomere length maintenance to the Tor protein kinases, which are central regulators of cellular growth. Here we summarize these results, which suggest a link between nutrient availability, telomere length maintenance and chronological lifespan.

Reference Type
Journal Article | Review | Research Support, Non-U.S. Gov't
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Kupiec M, Weisman R
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