Reference: Brogaard KR, et al. (2012) A chemical approach to mapping nucleosomes at base pair resolution in yeast. Methods Enzymol 513:315-34

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Abstract

Most eukaryotic DNA exists in DNA-protein complexes known as nucleosomes. The exact locations of nucleosomes along the genome play a critical role in chromosome functions and gene regulation. However, the current methods for nucleosome mapping do not provide the necessary accuracy to identify the precise nucleosome locations. Here we describe a new experimental approach that directly maps nucleosome center locations in vivo genome-wide at single base pair resolution.CI - Copyright (c) 2012 Elsevier Inc. All rights reserved.

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Journal Article
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Brogaard KR, Xi L, Wang JP, Widom J
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