Reference: Lo TL, et al. (2012) The mRNA decay pathway regulates the expression of the Flo11 adhesin and biofilm formation in Saccharomyces cerevisiae. Genetics 191(4):1387-91

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Abstract


Regulation of the FLO11 adhesin is a model for gene expression control by extracellular signals and developmental switches. We establish that the major mRNA decay pathway regulates FLO11 expression. mRNA deadenylation of transcriptional repressors of FLO11 by the exonuclease Ccr4 keeps their levels low, thereby allowing FLO11 transcription.

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Journal Article
Authors
Lo TL, Qu Y, Uwamahoro N, Quenault T, Beilharz TH, Traven A
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