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Reference: Zhang A and Gao W (2012) Mechanisms of protein kinase Sch9 regulating Bcy1 in Saccharomyces cerevisiae. FEMS Microbiol Lett 331(1):10-6

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Abstract

In this study, we investigated the mechanisms of Sch9 regulating the localization and phosphorylation of Bcy1. Our research indicated that Sch9 regulated localization of Bcy1 via Zds1 for the following reasons: (1) deletions of SCH9 or ZDS1 both caused nuclear localization of Bcy1; (2) Sch9 and Zds1 interacted physically; (3) overexpression of ZDS1 led to a significantly increased cytoplasmic localization of Bcy1 in sch9? cells, whereas overexpression of SCH9 had no visible effect on cytoplasmic localization of Bcy1 in zds1? cells. Our study also suggested that Sch9 regulated phosphorylation of Bcy1 via Yak1.

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Letter
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Zhang A, Gao W
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