Reference: Almstetter MF, et al. (2012) Comprehensive two-dimensional gas chromatography in metabolomics. Anal Bioanal Chem 402(6):1993-2013

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Abstract


One of the major objectives in metabolomics is the identification of subtle changes in metabolite profiles as affected by genetic or environmental factors. Comprehensive two-dimensional gas chromatography (GC ? GC) hyphenated to a fast-acquisition mass spectrometer is a well-established analytical technique to study the composition of complex samples due to its enhanced separation capacity, sensitivity, peak resolution, and reproducibility. This review reports applications of GC ? GC to metabolomics studies of sample of different types (biofluid, cells, tissue, bacteria, yeast, plants), and discusses its advantages and limitations.

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Journal Article
Authors
Almstetter MF, Oefner PJ, Dettmer K
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