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Reference: Benitez EM, et al. (2011) Yos9, a control protein for misfolded glycosylated and non-glycosylated proteins in ERAD. FEBS Lett 585(19):3015-9

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Abstract

The endoplasmic reticulum (ER) is responsible for folding and delivery of secretory proteins to their site of action. One major modification proteins undergo in this organelle is N-glycosylation. Proteins that cannot fold properly will be directed to a process known as endoplasmic reticulum associated degradation (ERAD). Processing of N-glycans generates a signal for ERAD. The lectin Yos9 recognizes the N-glycan signal of misfolded proteins and acts as a gatekeeper for the delivery of these substrates to the cytoplasm for degradation. Presence of Yos9 accelerates degradation of the glycosylated model ERAD substrate CPY *. Here we show that Yos9 has also a control function in degradation of the unglycosylated ERAD substrate CPY *0000. It decelerates its degradation rate.CI - Copyright (c) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Benitez EM, Stolz A, Wolf DH
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