Reference: Breitenbach M, et al. (2012) The role of mitochondria in the aging processes of yeast. Subcell Biochem 57:55-78

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Abstract


This chapter reviews the role of mitochondriamitochondria and of mitochondrial metabolismmetabolism in the aging processes of yeast and the existing evidence for the "mitochondrial theory of agingmitochondrial theory of aging ". MitochondriaMitochondria are the major source of ATPATP in the eukaryotic cell but are also a major source of reactive oxygen speciesreactive oxygen species (ROS) and play an important role in the process of apoptosisapoptosis and aging. We are discussing the mitochondrial theory of agingmitochondrial theory of aging (TOA), its origin, similarity with other TOAs, and its ramifications which developed in recent decades. The emphasis is on mother cell-specific agingmother cell-specific aging and the RLSRLS (replicative lifespan) with only a short treatment of CLSCLS (chronological lifespan). Both of these aging processes may be relevant to understand also the aging of higher organisms, but they are biochemically very different, as shown by the fact the replicative aging occurs on rich media and is a defect in the replicative capacity of mother cells, while chronological aging occurs in postmitotic cells that are under starvation conditions in stationary phase leading to loss of viability, as discussed elsewhere in this book. In so doing we also give an overview of the similarities and dissimilarities of the various aging processes of the most often used model organisms for aging research with respect to the mitochondrial theory of agingmitochondrial theory of aging.

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Journal Article
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Breitenbach M, Laun P, Dickinson JR, Klocker A, Rinnerthaler M, Dawes IW, Aung-Htut MT, Breitenbach-Koller L, Caballero A, Nystrom T, ... Show all
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