Reference: Longo VD and Fabrizio P (2012) Chronological Aging in Saccharomyces cerevisiae. Subcell Biochem 57:101-21

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Abstract

The two paradigms to study aging in Saccharomyces cerevisiae are the chronological life spanchronological life span (CLS) and the replicative life spanreplicative life span (RLS). The chronological life span is a measure of the mean and maximum survival time of non-dividing yeast populations while the replicative life span is based on the mean and maximum number of daughter cells generated by an individual mother cell before cell division stops irreversibly. Here we review the principal discoveries associated with yeast chronological aging and how they are contributing to the understanding of the aging process and of the molecular mechanisms that may lead to healthy aging in mammals. We will focus on the mechanisms of life span regulation by the Tor/Sch9Tor/Sch9 and the Ras/adenylateRas/adenylate cyclase/PKA pathwayscyclase/PKA pathways with particular emphasis on those implicating age-dependent oxidativeoxidative stressstress and DNA damage/repairDNA damage/repair.

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Journal Article
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Longo VD, Fabrizio P
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