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Reference: Chen LJ, et al. (2011) The yeast prion protein Ure2: insights into the mechanism of amyloid formation. Biochem Soc Trans 39(5):1359-64

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Abstract


Ure2, a regulator of nitrogen metabolism, is the protein determinant of the [URE3] prion state in Saccharomyces cerevisiae. Upon conversion into the prion form, Ure2 undergoes a heritable conformational change to an amyloid-like aggregated state and loses its regulatory function. A number of molecular chaperones have been found to affect the prion properties of Ure2. The studies carried out in our laboratory have been aimed at elucidating the structure of Ure2 fibrils, the mechanism of amyloid formation and the effect of chaperones on the fibril formation of Ure2.

Reference Type
Journal Article
Authors
Chen LJ, Sawyer EB, Perrett S
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